Applebee's | IHOP
APPLEBEE'S GRILL + BAR
Restaurant in Sikeston (S. Main)
- Pick Up Inside
- Dine-In
- Online Ordering
- Sikeston Takeout
- Sikeston Delivery
Neighborhood Favorites at Applebee's Sikeston
Applebee’s is an American restaurant and bar and grill in Sikeston, near the corner of Brunt Boulevard & South Main Street. This New Madrid County restaurant sits in an area known for Missouri Bootheel cotton country, making it the perfect family-friendly place to eat for lunch, late-night dining, watch the game, or find happy hour or lunch specials in Sikeston. If dining in is not on the menu, this restaurant proudly offers restaurant delivery, takeout, and catering.
Whether grabbing dinner with friends, enjoying a family meal, or ordering takeout and delivery, you’ll love our delicious steaks, mouthwatering burgers, shareable appetizers, and famous boneless wings tossed in signature sauces. Returning from an evening flight from CGI airport? Applebee’s is open late just for you, with friendly bartenders ready to pour your favorite drink in a 16-oz glass or our special 20-oz Brewtus.
Get to Know This Applebee's on S. Main
Applebee’s in Sikeston opened its doors on April 28, 2026. Experience what makes it a go-to destination for burgers, steaks, appetizers, and boneless wings, all available for takeout and delivery in Sikeston.
Many of our regular guests are military veterans, and we’re honored to serve them year-round. If you are a veteran or active-duty service member, we invite you to join us and take part in our annual Veterans Day free meal offer. We also welcome Sikeston City Hall and Clinton Community Center employees, along with those visiting after a day at License Bureau of Sikeston MO.
Our Menu - Delicious Food Near You
From mouth-watering appetizers to flavorful entrees and tempting desserts, we offer a menu of dishes to satisfy every craving. Enjoy juicy burgers, fresh salads, and homestyle favorites. Visit your nearest neighborhood Applebee's location on S. Main and savor the flavors of our menu today! You can also enjoy the convenience of online ordering.
Irresistible Deals & Rewards At Applebee's On S. Main
At Applebee's, we offer irresistible deals, specials, and rewards to enhance your dining experience. Join us for Happy Hour in Sikeston and enjoy discounted drinks and appetizers. Take advantage of current Sikeston specials and promotions, and sign up for Club Applebee’s and receive exclusive perks.
The Applebee’s | IHOP location in Sikeston, MO does not participate in the IHOP Rewards program and PanCoins cannot be earned or redeemed. Please note that participation in the IHOP Rewards program may vary by location. For details on eligible locations and program terms, visit IHOP Rewards Program Terms.
Tips for New Visitors to Applebee's Sikeston
Check the weather before you come to eat with us. In Sikeston, we get as many as 50 inches of rain annually and average temperatures around 14.4°C/58.0°F. Summer highs are near 31.3°C/88.4°F, and winter lows are around -3.7°C/25.4°F. Dress accordingly!
Need An Excuse to Go Out to Eat?
Need some excuses to get out today? Head out for a picnic at Sikeston Park, West End Park, or Malone Park with our Fiesta Lime Chicken or Salads to-go. Or, after a hot day near Mississippi River or Lower Castor River, stop in for an Applewood-smoked burger and a cold draft beer.
Culture lovers touring Sikeston Depot Museum & Cultural Center or seeing a performance at Show Me Center can cap the day with one of our signature cocktails at the bar. Students from Southeast Missouri State University, Shawnee Community College, and Three Rivers College make us their favorite study-break spot, while shoppers at Mid-Towner Village appreciate our convenient location.
Local events such as Cape Girardeau Cape Farmer’s Market and Riverfest Cape Girardeau bring the community together, and fans of Southeast Missouri Redhawks and St. Louis Cardinals gather here before heading to the big game at Sikeston Jaycee Bootheel Rodeo and other popular arenas. If you decide to leave your car at home, the nearest bus stop is at a location available via your local transit system.
Sikeston Essential Services
Essential services like Sikeston Department of Public Safety and Sikeston Department of Public Safety are only blocks away, and you’ll find neighbors from Miner, Morehouse, Matthews, and Bertrand just down the road.